Anti-S-Nitrosocysteine Antibodies Are a Predictive Marker for Demyelination in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

• DOI: 10.1523/jneurosci.22-01-00123.2002
• Publication Date: 2018-04-05T00:15:54Z
• Authors: Anne I. Boullerne; José J. Rodrı́guez; Tarik Touil; Bruno Brochet; Stephan Schmidt; Nora D. Abrous; Michel Le Moal; Jeffrey R. Pua; Mark A. Jensen; Willy Mayo; Barry G. W. Arnason; Klaus G. Petry
• Keywords: Encephalomyelitis; Myelin oligodendrocyte glycoprotein

Multiple sclerosis (MS) is characterized by inflammation within the CNS. This inflammatory response associated with production of nitric oxide (NO) and NO-related species that nitrosylate thiols. We postulated MS patients would exhibit an antibody (Ab) directed against proteins containing S-nitrosocysteine (SNO-cysteine) showed anti-NO-cysteine Abs IgM isotype are in fact present sera some (Boullerne et al., 1995). report here presence a seemingly identical Ab SNO-cysteine acute model MS, experimental autoimmune encephalomyelitis (EAE) induced Lewis rats 68-84 peptide guinea pig myelin basic protein (MBP(68-84)). Serum levels anti-SNO-cysteine peaked 1 week before onset clinical signs well appearance anti-MBP(68-84) Abs. The peak titer correlated extent subsequent CNS demyelination, suggesting link between level lesion formation. In relapsing-remitting patients, we found elevated at times relapse normal values most judged to be remission. Two-thirds secondary progressive had levels, including those receiving interferon beta-1b. data show rise circulating precedes EAE. Anti-SNO-cysteine also attacks disease, possible role for these Abs, measurable blood, as biological marker activity.