Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury

• DOI: 10.1523/jneurosci.22-15-06578.2002
• Publication Date: 2018-04-13T22:27:17Z
• Authors: Bharatkumar N. Patel; Robert J. Dunn; Suh Young Jeong; Qinzhang Zhu; Jean-Pierre Julien; Samuel David
• Keywords: Ceruloplasmin; Homeostasis

Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We have previously reported glycosylphosphatidylinositol-anchored form of ceruloplasmin expressed in the mammalian CNS. To better understand role homeostasis CNS, we generated gene-deficient (<i>Cp</i>^−/−) mouse. Adult<i>Cp</i>^−/− mice showed increased deposition several regions CNS such as cerebellum and brainstem. Increased lipid peroxidation was also seen some regions. Cerebellar cells from neonatal<i>Cp</i>^−/− were more susceptible oxidative stress <i>in vitro</i>.<i>Cp</i>^−/− deficits motor coordination associated with loss brainstem dopaminergic neurons. These results indicate plays an important maintaining protecting iron-mediated free radical injury. Therefore, antioxidant effects could implications for various neurodegenerative diseases Parkinson9s disease Alzheimer9s which known occur.