Dissociating Linguistic Processes in the Left Inferior Frontal Cortex with Transcranial Magnetic Stimulation
Adult
Male
frontotemporal connections
03 medical and health sciences
0302 clinical medicine
Broca's area
Reaction Time
Humans
MODULATION
Dominance, Cerebral
semantics
COMMON
Language
Brain Mapping
Science & Technology
language
LEFT PREFRONTAL CORTEX
Neurosciences
DYNAMIC APHASIA
REGIONS
Transcranial Magnetic Stimulation
ANATOMY
Frontal Lobe
phonology
Acoustic Stimulation
WORD RECOGNITION
TMS
EXCITABILITY
PATTERNS
Female
Neurosciences & Neurology
Life Sciences & Biomedicine
FUNCTIONAL-ORGANIZATION
Photic Stimulation
DOI:
10.1523/jneurosci.2307-05.2005
Publication Date:
2005-08-31T19:18:36Z
AUTHORS (3)
ABSTRACT
Is the left inferior frontal cortex (LIFC) a single functional region, or can it be subdivided into distinct areas that contribute differently to word processing? Here we used transcranial magnetic stimulation (TMS) to investigate anterior and posterior LIFC when the meaning and sound of words were being processed. Relative to no stimulation, TMS of the anterior LIFC selectively increased response latencies when participants focused on the meaning of simultaneously presented words (i.e., synonym judgments) but not when they focused on the sound pattern of the words (i.e., homophone judgments). In contrast, the opposite dissociation was observed in the posterior LIFC, where stimulation selectively interfered with the phonological but not the semantic task. This double dissociation shows functionally distinct subdivisions of the LIFC that can be understood in terms of separable corticocortical connections linking the anterior LIFC to temporal pole regions associated with semantic memory and the posterior LIFC to temporoparietal regions involved in auditory speech processing.
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CITATIONS (276)
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