Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity

• DOI: 10.1523/jneurosci.2504-16.2016
• Publication Date: 2016-12-31T02:10:29Z
• Authors: Kristian Kinden L...; Mikkel Elle Lepperød; Gunnar Dick; Torkel Hafting; Marianne Fyhn
• Keywords: Perineuronal net; Monocular deprivation; Premovement neuronal activity

Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end period heightened visual cortex plasticity in juveniles, whereas removal adults reopens for plasticity. mechanisms underlying this phenomenon remain elusive. We have used chronic electrophysiological recordings to investigate accompanying changes activity-dependent and we report on novel involved both induced critical By inducing adult rats while recording single unit population activity, demonstrate that PNN alters balance between excitatory spiking activity directly. Without PNNs, was reduced, variability increased as predicted a simulation Brunel neural network. Together shift ocular dominance large effects during first 48 h monocular deprivation (MD), show resets network an immature, juvenile state. Furthermore, PNN-depleted well MD caused immediate potentiation gamma suggesting mechanism initiating driving rapid activity.