Immune Quiescence of the Brain Is Set by Astroglial Connexin 43

• DOI: 10.1523/jneurosci.2575-14.2015
• Publication Date: 2015-03-11T16:33:23Z
• Authors: Anne-Cécile Boulay; Aurélien Mazeraud; Salvatore Cisternino; Bruno Saubaméa; Phillipe Mailly; Laurent Jourdren; Corinne Blugeon; Virginie Mignon; Maria Smirnova; Alessia Cavallo; Pascal Ezan; Patrick Avé; Florent Dingli; Damarys Loew; Paulo Vieira; Fabrice Chrétien; Martine Cohen-Salmon
• Keywords: Male; 0301 basic medicine; connexin; CD3 Complex; [SDV]Life Sciences [q-bio]; [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology; Mice; 03 medical and health sciences; astrocyte; immune quiescence; Cell Movement; Albumins; Glial Fibrillary Acidic Protein; Leukocytes; Animals; Cells, Cultured; Carbon Isotopes; autoimmunity; Calcium-Binding Proteins; Age Factors; Brain; Endothelial Cells; blood-brain barrier; Immunity, Humoral; 3. Good health; Blood-Brain Barrier; Astrocytes; Connexin 43; [SDV.IMM]Life Sciences [q-bio]/Immunology; Cytokines; Female

In the normal brain, immune cell trafficking and responses are strictly controlled limited. This unique homeostatic equilibrium, also called brain quiescence, is crucial to maintaining proper functions altered in various pathological processes, from chronic immunopathological disorders cognitive psychiatric impairments. To date, precise nature of factors regulating brain/immune system interrelationship poorly understood. present study, we demonstrate that one these Connexin 43 (Cx43), a gap junction protein highly expressed by astrocytes at blood–brain barrier (BBB) interface. We show that, setting activated state cerebral endothelium, astroglial Cx43 controls recruitment as well antigen presentation mechanisms mouse brain. Consequently, absence Cx43, recruited cells elaborate specific humoral autoimmune response against von Willebrand factor A domain-containing 5a, an extracellular matrix Altogether, our results new promoting quiescence