Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism

• DOI: 10.1523/jneurosci.2694-20.2021
• Publication Date: 2021-05-18T17:50:17Z
• Authors: Liqiang Chen; Samuel Daniels; Yerim Kim; Hong-Yuan Chu
• Keywords: Pyramidal cell

The hypokinetic motor symptoms of Parkinson's disease (PD) are closely linked with a decreased cortical output as consequence elevated basal ganglia inhibition. However, whether and how the loss dopamine (DA) alters cellular properties neurons in PD remains undefined. We induced parkinsonism adult C57BL/6 mice both sexes by injecting neurotoxin, 6-hydroxydopamine (6-OHDA), into medial forebrain bundle. By using