Information Processing Architecture of Functionally Defined Clusters in the Macaque Cortex

• DOI: 10.1523/jneurosci.2709-12.2012
• Publication Date: 2012-11-28T17:43:04Z
• Authors: Kelly Shen; Gleb Bezgin; R. Matthew Hutchison; Joseph S. Gati; Ravi S. Menon; Stefan Everling; Anthony R. McIntosh
• Keywords: Functional organization; Tracing

Computational and empirical neuroimaging studies have suggested that the anatomical connections between brain regions primarily constrain their functional interactions. Given large-scale organization of networks is determined by temporal relationships regions, structural limitations may extend to global characteristics networks. Here, we explored extent which network community structure underlying architecture. We directly compared macaque ( Macaca fascicularis ) connectivity (FC) assessed using spontaneous blood oxygen level-dependent magnetic resonance imaging (BOLD-fMRI) directed derived from axonal tract tracing studies. Consistent with previous reports, FC increased increasing strength connection, was also present had no direct connection. observed moderate similarity each region its connectivity. Notably, patterns, as described motifs, were different within across modules: partitioning supported dense bidirectional clusters unidirectional clusters. Together, our data demonstrate patterns in resting-state BOLD-fMRI are dictated neuroanatomical Importantly, show how this architecture contributes organizational principles both specialization integration.