2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination

Remyelination 2-Arachidonoylglycerol Encephalomyelitis
DOI: 10.1523/jneurosci.2900-16.2017 Publication Date: 2017-07-28T01:00:39Z
ABSTRACT
The failure to undergo remyelination is a critical impediment recovery in multiple sclerosis. Chondroitin sulfate proteoglycans (CSPGs) accumulate at demyelinating lesions creating nonpermissive environment that impairs axon regeneration and remyelination. Here, we reveal new role for 2-arachidonoylglycerol (2-AG), the major CNS endocannabinoid, modulation of CSPGs deposition progressive model sclerosis, Theiler9s murine encephalomyelitis virus-induced disease. Treatment with potent reversible inhibitor enzyme monoacylglycerol lipase, which accounts 85% 2-AG degradation mouse CNS, modulates neuroinflammation reduces accumulation astrogliosis around demyelinated spinal cord virus-infected mice. Inhibition hydrolysis augments number mature oligodendrocytes increases MBP, leading functional Our findings establish mechanism promotion implications axonal repair pathologies. <b>SIGNIFICANCE STATEMENT</b> chondroitin contributes associated Here unveil 2-arachidonoylglycerol, proteoglycan treatment during chronic phase increased tone promotes sclerosis ameliorating motor dysfunction.
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