Regulation of IL-10 by Chondroitinase ABC Promotes a Distinct Immune Response following Spinal Cord Injury

• DOI: 10.1523/jneurosci.2927-14.2014
• Publication Date: 2014-12-03T19:04:16Z
• Authors: Athanasios Didang...; Michaela Iberl; Elin Vinsland; Katalin Bartus; Elizabeth J. Brad...
• Keywords: Macrophage polarization; Proinflammatory cytokine

Chondroitinase ABC (ChABC) has striking effects on promoting neuronal plasticity after spinal cord injury (SCI), but little is known about its involvement in other pathological mechanisms. Recent work showed that ChABC might also modulate the immune response by M2 macrophage polarization. Here we investigate detail immunoregulatory of SCI rats. Initially, examined expression profile 16 M1/M2 polarization markers at 3 h and 7 d postinjury. treatment had a clear effect signature SCI. More specifically, increased anti-inflammatory cytokine IL-10, accompanied reduction proinflammatory IL-12B injured tissue. These were associated with distinct, IL-10-mediated ChABC-treated cords. Mechanistically, show IL-10 driven tissue infiltration, while p38 MAPK central regulator vivo . findings provide novel insights into explain activity.