The Architecture of Functional Interaction Networks in the Retina
Male
Retinal Ganglion Cells
0301 basic medicine
0303 health sciences
03 medical and health sciences
Neural Pathways
Action Potentials
Animals
Female
Nerve Net
Ambystoma
Retina
DOI:
10.1523/jneurosci.3682-10.2011
Publication Date:
2011-02-24T03:29:34Z
AUTHORS (3)
ABSTRACT
Sensory information is represented in the brain by the joint activity of large groups of neurons. Recent studies have shown that, although the number of possible activity patterns and underlying interactions is exponentially large, pairwise-based models give a surprisingly accurate description of neural population activity patterns. We explored the architecture of maximum entropy models of the functional interaction networks underlying the response of large populations of retinal ganglion cells, in adult tiger salamander retina, responding to natural and artificial stimuli. We found that we can further simplify these pairwise models by neglecting weak interaction terms or by relying on a small set of interaction strengths. Comparing network interactions under different visual stimuli, we show the existence of local network motifs in the interaction map of the retina. Our results demonstrate that the underlying interaction map of the retina is sparse and dominated by local overlapping interaction modules.
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