Spatial Exploration-InducedArcmRNA and Protein Expression: Evidence for Selective, Network-Specific Reactivation

• DOI: 10.1523/jneurosci.4342-04.2005
• Publication Date: 2005-02-16T20:58:29Z
• Authors: Victor Ramírez-Amaya; Almira Vazdarjanova; Dalia Mikhael; Susanna Rosi; Paul F. Worley; Carol A. Barnes
• Keywords: Biological neural network; Immediate early gene

The immediate-early gene Arc is transcribed in neurons that are part of stable neural networks activated during spatial exploratory behaviors. protein has been demonstrated to regulate AMPA-type glutamate receptor trafficking by recruiting endosomal pathways, suggesting a direct role synaptic plasticity. purpose the present study examine fidelity mRNA translation and temporal dynamics behaviorally induced expression after rats explore novel environment. These experiments reveal two waves single exploration session. In initial wave, virtually all cells express hippocampus parietal cortex also protein, indicating, at cellular level, transcription closely correlated from 30 min 2 h hippocampal CA neurons. A second wave spans interval 8 24 remarkably specific active original behavior-induced network. This detected subset network displays property proportions Arc-positive become among regions h. suggests driven activity, stabilization circuits reflecting behavioral experience may occur temporally discrete phases, as memories consolidated. first demonstration network-selective translational events consequent behavior for genes circuit-specific, late-phase biology.