Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

• DOI: 10.1523/jneurosci.4943-09.2009
• Publication Date: 2009-12-16T18:23:44Z
• Authors: Julien Vezoli; Emmanuel Procyk
• Keywords: Frontal cortex

Feedback monitoring and adaptation of performance involve a medial reward system including frontal cortical areas, the striatum, dopaminergic system. A considerable amount data has been obtained on surface feedback-related potentials (FRPs) in humans correlate outcome with single unit activity monkeys. However, work is needed to bridge knowledge two species. The present describes FRPs monkeys, using chronic recordings, during trial error task. We show that are differentially sensitive successes failures can be observed over long-term periods. In addition, dopamine antagonist haloperidol we observe selective effect FRP amplitude absent for pure sensory-related potentials. These results describe dopaminergic-dependent monkeys corroborate human-monkey homology signals.