Altered Resting-State Functional Connectivity in Cortical Networks in Psychopathy

• DOI: 10.1523/jneurosci.5010-14.2015
• Publication Date: 2015-04-15T16:37:33Z
• Authors: Carissa L. Philippi; Maia S. Pujara; Julian C. Motzkin; Joseph Newman; Kent A. Kiehl; Michael Koenigs
• Keywords: Adult; Cerebral Cortex; Male; Brain Mapping; Rest; Antisocial Personality Disorder; Magnetic Resonance Imaging; 3. Good health; Oxygen; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Neural Pathways; Image Processing, Computer-Assisted; Humans; Regression Analysis; Nerve Net

Psychopathy is a personality disorder characterized by callous antisocial behavior and criminal recidivism. Here we examine whether psychopathy associated with alterations in functional connectivity three large-scale cortical networks. Using fMRI 142 adult male prison inmates, computed resting-state using seeds from the default mode network, frontoparietal cingulo-opercular network. To determine specificity of our findings to these networks, also calculated two comparison primary sensory networks: visual auditory Regression analyses related network overall scores subscores for “factors” “facets” psychopathy: Factor 1, interpersonal/affective traits; 2, lifestyle/antisocial Facet interpersonal; affective; 3, lifestyle; 4, antisocial. Overall severity was reduced between lateral parietal cortex dorsal anterior cingulate cortex. The factor exhibited contrasting relationships connectivity: 1 were whereas 2 heightened same This dissociation evident particularly insula facet demonstrated distinct patterns connectivity. We found no associations within or These provide novel evidence on neural correlates suggest that association hubs, such as cortex, may be neurobiological marker disorder.