Long-Term Temporal Imprecision of Information Coding in the Anterior Cingulate Cortex of Mice with Peripheral Inflammation or Nerve Injury

• DOI: 10.1523/jneurosci.5166-13.2014
• Publication Date: 2014-08-06T16:28:56Z
• Authors: X.-Y. Li; N. Wang; Y.-J. Wang; Z.-X. Zuo; K. Koga; F. Luo; M. Zhuo
• Keywords: Peripheral nerve injury

Temporal properties of spike firing in the central nervous system (CNS) are critical for neuronal coding and precision information storage. Chronic pain has been reported to affect cognitive emotional functions, addition trigger long-term plasticity sensory synapses behavioral sensitization. Less is known about possible changes temporal cortical neurons chronic conditions. In present study, we investigated action potential anterior cingulate cortex (ACC) by using both <i>in vivo</i> vitro</i> electrophysiological approaches. We found that peripheral inflammation caused complete Freund9s adjuvant (CFA) increased standard deviation (SD) spikes latency (also called jitter) ∼51% recorded ACC adult rats vivo</i>. Similar increases jitter were brain slices from mice with or nerve injury. Bath application glutamate receptor antagonists CNQX AP5 abolished enhancement induced CFA injection injury, suggesting depends on glutamatergic synaptic transmission. Activation adenylyl cyclases (ACs) bath forskolin jitter, whereas genetic deletion AC1 change inflammation. Our study provides strong evidence after injuries explains mechanism impairment.