Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety

• DOI: 10.1523/jneurosci.5836-10.2011
• Publication Date: 2011-04-20T17:03:10Z
• Authors: Jesse W. Richards...; Caryne P. Craige; Thanh H. Nguyen; Hank F. Kung; Alain M. Gardier; Alex Dranovsky; Denis J. David; Bruno P. Guiard; Sheryl G. Beck; René Hen; E. David Leonardo
• Keywords: Autoreceptor

Identifying the factors contributing to etiology of anxiety and depression is critical for development more efficacious therapies. Serotonin (5-HT) intimately linked both disorders. The inhibitory serotonin-1A (5-HT 1A ) receptor exists in two separate populations with distinct effects on serotonergic signaling: (1) an autoreceptor that limits 5-HT release throughout brain (2) a heteroreceptor mediates responses released 5-HT. Traditional pharmacologic transgenic strategies have not addressed roles these populations. Here we use recently developed genetic mouse system independently manipulate We show autoreceptors act affect anxiety-like behavior. In contrast, heteroreceptors forced swim stress, without Together our previously reported work, results establish populations, providing evidence signaling through endogenous necessary sufficient establishment normal