Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis

• DOI: 10.1523/jneurosci.5855-12.2013
• Publication Date: 2013-05-08T16:38:10Z
• Authors: Friederike Klempin; Daniel Beis; Valentina Mosienko; Gerd Kempermann; Michael Bader; Natalia Alenina
• Keywords: TPH2

Voluntary wheel running has long been known to induce precursor cell proliferation in adult hippocampal neurogenesis rodents. However, mechanisms that couple activity with the promitotic effect are not yet fully understood. Using tryptophan hydroxylase (TPH) 2 deficient ( Tph2 -deficient) mice lack brain serotonin, we explored relationship between serotonin signaling and exercise-induced neurogenesis. Surprisingly, -deficient exhibit normal baseline but impaired activity-induced proliferation. Our data demonstrate proproliferative of requires release central young-adult aged mice. Lack further results alterations at stage Sox2-positive cells, suggesting physiological adaptations changes supply maintain homeostasis neurogenic niche. We conclude plays a direct acute regulatory role activity-dependent The understanding might offer preventive also therapeutic opportunities depression age-related cognitive decline.