Adult neural stem cells and neurogenesis are resilient to intermittent fasting

• DOI: 10.15252/embr.202357268
• Publication Date: 2023-11-22T19:13:59Z
• Authors: Rut Gabarró‐Solanas; Amarbayasgalan Da...; Justus Kleifeld; Tatjana Kepčija; Thomas Köcher; Albert Giralt; Iván Crespo‐Enríquez; Noelia Urbán
• Keywords: Neurons; Mice; Adult Stem Cells; Neural Stem Cells; Neurogenesis; Intermittent Fasting; Animals; Articles; Hippocampus

Intermittent fasting (IF) is a promising strategy to counteract ageing shown increase the number of adult-born neurons in dentate gyrus mice. However, it unclear which steps adult neurogenesis process are regulated by IF. The neural stem cells (NSCs) decreases with age an activation-dependent manner and, this loss, NSCs found quiescent state ensures their long-term maintenance. We aimed determine if and how IF affects hippocampus. To identify effects every-other-day on all following neurogenic lineage, we combined lineage tracing label retention assays. show here that does not affect NSC activation or maintenance contrary previous reports, neurogenesis. same results obtained regardless strain, sex, diet length, tamoxifen administration new-born neuron identification method. Our data suggest maintain homeostasis upon intervention reliable