Long non‐coding RNA MALAT 1 regulates retinal neurodegeneration through CREB signaling
0301 basic medicine
Medicine (General)
retinal neurodegeneration
QH426-470
Retina
Rats, Sprague-Dawley
reactive gliosis
Mice
03 medical and health sciences
R5-920
Partial Retraction
Genetics
Animals
Humans
Phosphorylation
Cyclic AMP Response Element-Binding Protein
Research Articles
0303 health sciences
Neurodegenerative Diseases
long non‐coding RNA
RNA, Long Noncoding
CREB signaling
Corrigendum
Protein Processing, Post-Translational
Protein Binding
Signal Transduction
DOI:
10.15252/emmm.201505725
Publication Date:
2016-03-11T02:09:51Z
AUTHORS (16)
ABSTRACT
The nervous and vascular systems, although functionally different, share many common regulators of function maintenance. Long non-coding RNAs (lncRNAs) are important players in biological processes human disorders. We previously identified a role MALAT1 microvascular dysfunction. However, its neurodegeneration is still unknown. Here, we used the eye as model to investigate retinal neurodegeneration. show that expression significantly up-regulated retinas, Müller cells, primary ganglion cells (RGCs) upon stress. knockdown reduces reactive gliosis, cell activation, RGC survival vivo vitro MALAT1-CREB binding maintains CREB phosphorylation by inhibiting PP2A-mediated dephosphorylation, which leads continuous signaling activation. Clinical animal experimentation suggests dysfunction implicated neurodegenerative several Collectively, this study reveals might regulate development through signaling.
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CITATIONS (78)
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