Long non‐coding RNA MALAT 1 regulates retinal neurodegeneration through CREB signaling

0301 basic medicine Medicine (General) retinal neurodegeneration QH426-470 Retina Rats, Sprague-Dawley reactive gliosis Mice 03 medical and health sciences R5-920 Partial Retraction Genetics Animals Humans Phosphorylation Cyclic AMP Response Element-Binding Protein Research Articles 0303 health sciences Neurodegenerative Diseases long non‐coding RNA RNA, Long Noncoding CREB signaling Corrigendum Protein Processing, Post-Translational Protein Binding Signal Transduction
DOI: 10.15252/emmm.201505725 Publication Date: 2016-03-11T02:09:51Z
ABSTRACT
The nervous and vascular systems, although functionally different, share many common regulators of function maintenance. Long non-coding RNAs (lncRNAs) are important players in biological processes human disorders. We previously identified a role MALAT1 microvascular dysfunction. However, its neurodegeneration is still unknown. Here, we used the eye as model to investigate retinal neurodegeneration. show that expression significantly up-regulated retinas, Müller cells, primary ganglion cells (RGCs) upon stress. knockdown reduces reactive gliosis, cell activation, RGC survival vivo vitro MALAT1-CREB binding maintains CREB phosphorylation by inhibiting PP2A-mediated dephosphorylation, which leads continuous signaling activation. Clinical animal experimentation suggests dysfunction implicated neurodegenerative several Collectively, this study reveals might regulate development through signaling.
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