Evaluation of determinants of the serological response to the quadrivalent split‐inactivated influenza vaccine

• DOI: 10.15252/msb.202110724
• Publication Date: 2022-05-06T07:30:12Z
• Authors: Shaohuan Wu; Ted M Ross; Michael A Carlock; Elodie Ghedin; Hyungwon Choi; Christine Vogel
• Keywords: Seroconversion; Hemagglutination assay

The seasonal influenza vaccine is only effective in half of the vaccinated population. To identify determinants efficacy, we used data from > 1,300 vaccination events to predict response measured as seroconversion well hemagglutination inhibition (HAI) titer levels one year after. We evaluated predictive capabilities age, body mass index (BMI), sex, race, comorbidities, history, and baseline HAI titers, month dose multiple linear regression models. models predicted categorical for 75% cases all subsets with exception. Prior vaccination, level, age were major seroconversion, which had negative effects. Further, identified a gender effect older participants an month. BMI surprisingly small effect, likely due its correlation age. Comorbidities, dose, race negligible Our can generate new score that corrected impact these factors facilitate future biomarker identification.