Developmental aspects of prolactin receptor gene expression in fetal and neonatal mice

• DOI: 10.1530/eje.0.1340751
• Publication Date: 2008-12-15T22:12:49Z
• Authors: Holly M Brown-Borg; Fu-Ping Zhang; Ilpo Huhtaniemi; Andrzej Bartke
• Keywords: Prolactin receptor

Brown-Borg HM, Zhang F-P, Huhtaniemi I, Bartke A. Developmental aspects of prolactin receptor gene expression in fetal and neonatal mice. Eur J Endocrinol 1996;134:751–7. ISSN 0804–4643 The (PRL-R), a member the hematopoietin cytokine superfamily, is widely distributed among mammalian tissues. To understand better potential sites action onset PRL responsiveness, developmental distribution pattern PRL-R mRNA mice was examined. Fetal mouse tissues were collected at distinct stages from timed pregnancies. Following extraction total RNA, evaluated via reverse transcription-polymerase chain reaction (RT-PCR) Southern hybridization employed for verification. Expression first observed on day 14 liver cranium 15 kidney, lung thymus gland. Pituitary adrenal glands positive 18 gestation through to 1 postnatal life. Neither whole fetuses prior (days 10–13) nor skin bladder 2-day-old generated detectable RT-PCR signals PRL-R. presence spleen suggests possible role development immune system. Prolactin may act directly pituitary influence its own secretion and/or that other pituitary-derived factors, as evidenced by 1-day-old These data are show various organ systems suggest several factors necessary coordinate activities. Holly M Brown-Borg, Department Physiology, University North Dakota School Medicine, Grand Forks, ND 58202-9037, USA