The artificial sweetener erythritol and cardiovascular event risk

• DOI: 10.1530/ey.20.12.13
• Publication Date: 2023-09-11T07:57:06Z
• Authors: Witkowski M; Nemet I; Alamri H; Wilcox J; Gupta N; Nimer N; Haghikia A; Li XS; Wu Y; Saha PP; Demuth I; Konig M; Steinhagen-Thiess...; Cajka T; Fiehn O; Landmesser U; Tang WHW; Hazen SL
• Keywords: Artificial Sweetener; Erythritol; Cardiovascular event

Brief summary: This observational study in three different cohorts found an increased risk for atherothrombotic disease associated with the commonly used sugar substitute erythritol. Untargeted metabolomics (in cohort 1, n=1157) and targeted 2 3, n=2149 USA n=833 Europe, respectively) investigations revealed major adverse cardiovascular events (MACE) including death, myocardial infarction stroke persons circulating levels of multiple polyol sweeteners such as At physiological levels, erythritol enhanced human platelet reactivity vitroin a dose-dependent manner; thrombosis formation mouse model.