High-fat diet aggravates glucose homeostasis disorder caused by chronic exposure to bisphenol A

• DOI: 10.1530/joe-13-0386
• Publication Date: 2014-02-06T05:45:03Z
• Authors: Shibin Ding; Ying Fan; Nana Zhao; Huiqin Yang; Xiaolei Ye; Dongliang He; Xin Jin; Jian Liu; Chong Tian; Hongyu Li; Shunqing Xu; Chenjiang Ying
• Keywords: Homeostasis

Epidemiological findings on the association between bisphenol A (BPA, 2,2- bis -(4-hydroxyphenyl)propane) exposure and type 2 diabetes mellitus (T2DM) are paradoxical. In animal studies, BPA has been shown to disrupt pancreatic function blood glucose homeostasis even at a reference ‘safe’ level during perinatal period. this study, we explored effects of long-term paternal parents themselves their offspring. Adult male genitor rats fed with either standard chow diet (STD) or high-fat (HFD) were treated respectively vehicle (50 μg/kg per day) for 35 weeks. The 21 weeks then used as sires, adult female STD gestation lactation. Offspring weaned postnatal day in later life. Metabolic parameters recorded disrupted function, HFD aggravated these adverse effects. However, did not alter body weight, fat percentage, serum lipid. addition, cause reproductive consequence metabolic disorder Our indicate that chronic predicted dose contributes disorders, aggravates rats.