Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows
2. Zero hunger
Granulosa Cells
Postpartum Period
Gene Expression
Receptor, IGF Type 1
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 2
03 medical and health sciences
Insulin-Like Growth Factor Binding Protein 3
0302 clinical medicine
Follicular Phase
Insulin-Like Growth Factor Binding Protein 4
Ovarian Follicle
Insulin-Like Growth Factor II
Somatomedins
Animals
Cattle
Female
RNA, Messenger
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 5
Insulin-Like Growth Factor Binding Protein 6
In Situ Hybridization
DOI:
10.1530/rep-06-0122
Publication Date:
2007-03-22T13:51:21Z
AUTHORS (6)
ABSTRACT
Post partum negative energy balance (NEB) in dairy cattle is associated with a delayed return to ovarian cyclicity and reduced fertility. This study compared the IGF system of pre-recruitment follicles between cows mild ( n = 6) or severe NEB during early lactation. Ovaries were collected second week post , when circulating concentrations IGF-I glucose lower P < 0.01) cows. mRNA expression for IGF-II, type 1 receptor (IGF-1R) IGF-binding proteins (IGFBP)-1 IGFBP-6 was determined by situ hybridisation individual using radiolabelled oligonucleotide probes. Follicles classified as very small (1–2.5 mm) (2.5–5 healthy atretic. Relative measured optical density (OD) units image analysis. Thecal IGF-II highest small, 0.05). Granulosa cell IGFBP-2 only component change EB status, higher IGFBP-1 IGFBP-3 undetectable. IGF-1R, IGFBP-4 IGFBP-5 not significantly altered follicle size health, but tended increase atretic follicles. The pattern theca paralleled that mRNA, 0.05) levels healthy, In conclusion, may alter bioavailability locally produced modulate stages required maintain normal cyclicity.
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