Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus)

• DOI: 10.1530/rep-12-0373
• Publication Date: 2013-02-22T03:56:35Z
• Authors: Joachim Wistuba; C Marc Luetjens; Jens Ehmcke; Klaus Redmann; Oliver S Damm; Antje Steinhoff; Reinhild Sandhowe...; Eberhard Nieschlag; Manuela Simoni; Stefan Schlatt
• Keywords: Regimen

Marmosets are used as preclinical model in reproductive research. In contrast to other primates, they display short gestation times rendering this species valid for exploration of effects on fertility. However, their peculiar endocrine regulation differs from a those macaques and humans. We subjected male marmosets previously clinically tested hormonal regimens that known effectively suppress spermatogenesis. Beside control group, seven groups (each n=6) were investigated different periods up 42 months: regimen I, (four groups) received testosterone undecanoate (TU) norethisterone enanthate (NETE); II, (two TU NETE followed by only; III, (one group) only. Testicular volume, cell ploidy histology, changes fertility monitored weekly. initial treatment failed spermatogenesis volumes dropped, although was only mildly affected; however, testicular cellular composition remained stable. Serum dropped when given alone but the animals fertile. Compared with controls, no significant observed sperm motility Administration affected function mildly, indicating regulatory role chorionic gonadotrophin is obviously limited maintained, axis treatment. conclusion, showed response contraception or men have be considered problematic trials contraception.