Cytomegalovirus Seropositivity is Associated with Airflow Limitation in a Cohort of Veterans with a High Prevalence of Smoking

• DOI: 10.15326/jcopdf.2021.0221
• Publication Date: 2021-07-30T20:29:07Z
• Authors: Robert Burkes; Andrew Osterburg; Timothy Hwalek; Laura Lach; Ralph J. Panos; Michael T. Borchers
• Keywords: Serostatus

Cytomegalovirus (CMV) represents an understudied chronic infection, usually contracted early in life, that causes immune system alterations which may contribute to airflow limitations a cohort of veterans with high prevalence smoking. We studied 172 participants at-risk for and limitation available CMV serology assess the relationship between infection obstructive pulmonary disease (COPD)-related outcomes.The study includes who are smokers or at risk development COPD. Clinical data were obtained by chart abstraction enrollment. affinity (ever-exposure) avidity testing (length exposure) performed on plasma samples collected Bivariable multivariable logistic regression was used determine both cytomegalovirus odds prevalent (post-bronchodilator forced expiratory volume 1 second vital capacity ratio <0.70) In those (n=84), bivariable relationships serostatus reported exacerbations COPD over 2 years prior enrollment.Positive independently associated 136% higher (95% confidence interval 1.11-5.06, P=0.03) Neither nor enrollment.CMV is smoke. Investigation into timing cellular immunity caused smoking-related airways disease-related outcomes warranted.