Mechanism of Pressure-Overload Right Ventricular Hypertrophy in Infant Rabbits

• DOI: 10.1536/ihj.52.56
• Publication Date: 2011-02-10T06:05:52Z
• Authors: Sachito Minegishi; Kazuo Kitahori; Arata Murakami; Minoru Ono
• Keywords: Pressure overload; Right ventricular hypertrophy; Ventricular pressure; Masson's trichrome stain; Volume overload; Ventricular hypertrophy

Although pressure-overload right ventricular hypertrophy is a long-term risk in some congenital heart diseases such as tetralogy of Fallot, how it develops unclear. The aim this study was to investigate the mechanism development failure.Pulmonary artery banding 10-day-old rabbits induced they grew. Comparisons were made with age-matched sham controls (n = 24 per group). In weekly serial echocardiography, contraction and diastolic function decreased from 3 weeks after surgery (P < 0.01), ventricle became hypertrophic 4 0.05). Pressure-overload increased cardiomyocyte apoptosis postoperatively (TUNEL staining Western blotting analysis, P 0.05); fibrosis occurred cardiomyocytes at 8 operation (Masson's trichrome stain, 0.01). our model, caused disorder, hypertrophy, fibrosis. Apoptosis involved progression. We have shown for first time whereby an infant rabbit model.