Comparison of Bacteriological, Genetic and Pathological Characters between Escherichia coli O115a,c:K(B) and Citrobacter rodentium.
DNA, Bacterial
Male
0301 basic medicine
Mice, Inbred BALB C
0303 health sciences
Hyperplasia
Colon
Sequence Homology
Sequence Analysis, DNA
3. Good health
Citrobacter freundii
Rodent Diseases
Colonic Diseases
Mice
03 medical and health sciences
RNA, Ribosomal, 16S
Escherichia coli
Animals
Germ-Free Life
Female
Disease Susceptibility
DOI:
10.1538/expanim.50.183
Publication Date:
2004-01-14T09:54:10Z
AUTHORS (9)
ABSTRACT
Murine pathogenic Escherichia coli O115a,c:K(B) (MPEC) is the causative agent of mouse megaenteron, the pathology of which resembles that of transmissible murine colonic hyperplasia caused by Citrobacter rodentium. We compared their genetic and pathological features to reveal the relationship between these two bacteria. To evaluate the genetic distances, 16S rDNA genes were sequenced and biochemical reactions were tested. Mouse strain susceptibility tests, using CF1 MPEC-susceptible germfree mice and BALB/cA(Jic) resistant mice were performed. MPEC strains and C. rodentium showed more than 99.6% identity by comparison of 16S rDNA gene sequences. All results from biochemical reactions and the mouse strain susceptibility tests were identical. It is proposed that MPEC should be reclassified as C. rodentium.
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