Diffuse Alveolar Lesion in BALB/c Mice Induced with Human Reovirus BYD1 Strain and its Potential Relation with SARS

• DOI: 10.1538/expanim.55.439
• Publication Date: 2006-11-08T05:46:47Z
• Authors: Cheng HE; Qi YANG; Ming LEI; Wanyong PANG; Jianmin YANG; Hong ZHU; Qing DUAN
• Keywords: Diffuse alveolar damage; Coagulative necrosis; Hyaline; White pulp; Alveolar Wall

The objective of this study was to investigate the pathogenicity and associated lesions a new reovirus (ReoV) isolated from patients with Severe Acute Respiratory Syndrome (SARS) in China. Twenty-five four-week-old BALB/c female mice inoculated intranasally either ReoV (strain BYD1) alone, or combined SARS-CoV BJF) displayed ejecting fur loss body weight compared control animals. were most postmortem tissues. histopathological features infected animals consisted diffuse alveolar damage, scattered hemorrhage, hyaline membrane formation interstitial pneumonia. A typical type II pneumocyte hyperplasia fibrogranulomatous tissue septae observed both simultaneously these two viruses firstly SARS-CoV, followed by ReoV. ReoV, hemorrhage septa. Furthermore, other above combination groups included depletion lymphocytes germinal center lymph nodes lung hilus spleen, hemorrhagic necrosis white pulp hydroid degeneration, fatty degeneration liver kidney. Mice induced alone did not display clinical signs, characteristically formation, early pulmonary fibrosis tissue. This demonstrated that newly might be virulent pathogen for mice. developed lesion.