Dependence of Intestinal Microbiota Composition on Distribution and Activity of Adipose Tissue in Nonalcoholic Fatty Liver Disease

• DOI: 10.15407/microbiolj84.03.051
• Publication Date: 2022-12-17T12:08:02Z
• Authors: G.D. Fadieienko; I.E. Kushnir; ; V.M. Chernova; ; T.A. Solomentseva; ; Ya.V. Nikiforova; ; O.H. Kurinna; ; V.Yu. Galchynska; ; T.N. Bondar
• Keywords: Dysbiosis; Pathogenesis; Steatosis

Nonalcoholic fatty liver disease (NAFLD) pathogenesis displays a close relation with intestinal dysbiosis. Thus, the aim of this study was to investigate microbiota (IM) composition and determine correlation changes in its main phylotypes amount activity adipose tissue NAFLD patients. Methods. The prospective enrolled 114 patients metabolic disorders 30 healthy subjects as control group. Along routine examination, authors assessed by identifying total bacterial DNA Bacteroidetes, Firmicutes, Actinobacteria means quantitative real-time PCR. Results. showed signifi cant decrease relative Bacteroidetes simultaneous increase Firmicutes an Firmicutes/Bacteroidetes ratio compared (p<0.05). concomitant overweight obesity displayed more significant imbalance IM due inhibition normal body mass index. revealed examined were proven linked not only weight but also visceral tissue. Furthermore, deviations gut had impact on formation severity steatosis. Conclusions. Further research will help elucidate their role lay foundation for development individualized treatment.