Hepatoprotective activity of exogenous RNA

• DOI: 10.15407/ubj87.04.037
• Publication Date: 2015-07-28T06:08:52Z
• Authors: I. O. Shmarakov; Т. V. Marchyshak; V. L. Borschovetska; M. M. Marchenko; Z. Yu. Tkachuk
• Keywords: Thioacetamide; Parenchyma; Thiol

Hepatoprotective activity of Nuclex, a pharmaceutical composed low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at dose 200 mg/kg liver injury produces hepatoprotective effect, which associated with decrease in parenchyma lesions its inflammatory infiltration. application attenuates free radical damage hepatic biopolymers, expressed the reduction TBA-reactive products, carbonyl derivatives, recovery protein thiol groups reduced glutathione levels.