Unique Cardiopulmonary Interactions in Congenital Diaphragmatic Hernia: Physiology and Therapeutic Implications
Pulmonary Hypoplasia
Maldevelopment
Pathophysiology
DOI:
10.1542/neo.24-11-e720
Publication Date:
2023-11-01T03:11:01Z
AUTHORS (6)
ABSTRACT
Congenital diaphragmatic hernia (CDH) results in abdominal contents entering the thoracic cavity, affecting both cardiac and pulmonary development. Maldevelopment of vasculature occurs within ipsilateral lung contralateral lung. The resultant bilateral hypoplasia associated hypertension are important components pathophysiology this disease that affect outcomes. Despite prenatal referral to specialized high-volume centers, advanced ventilation strategies, management, option extracorporeal membrane oxygenation, overall CDH mortality remains between 25% 30%. With increasing recognition dysfunction plays a large role morbidity patients with CDH, it becomes imperative understand different clinical phenotypes, thus allowing for individual patient-directed therapies. Further research into therapeutic interventions address cardiopulmonary interactions may lead improved
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