Natural History of Human Immunodefiency Virus Type 1 Infection in Children: A Five-Year Prospective Study in Rwanda

• DOI: 10.1542/peds.104.5.e56
• Publication Date: 2004-08-13T23:45:45Z
• Authors: Rosemary Spira; Philippe Lepage; Philippe Msellati; Philippe Van de P...; Valeriane Leroy; Arlette Simonon; Etienne Karita; François Dabis
• Keywords: Failure to Thrive

Objective. To compare morbidity and mortality of human immunodeficiency virus type 1 (HIV-1)-infected HIV-1-uninfected children to identify predictors acquired syndrome (AIDS) death among HIV-1-infected in the context a developing country. Design. Prospective cohort study. Setting. Maternal child health clinic Centre Hospitalier de Kigali, Rwanda. Participants. Two hundred eighteen born HIV-1-seropositive mothers 218 seronegative same age parity were enrolled at birth. Outcome Measures. Deaths, clinical AIDS, nonspecific HIV-related manifestations, use care services. Results. Fifty-four infected 347 uninfected followed up for median 27 51 months, respectively. With exception chronic cough, risk occurrence conditions was 3 13 times higher than children. The recurrence rate severity these findings increased systematically infants. Estimated cumulative AIDS 28% 35% 2 5 years age, 45% 62%, respectively, 21 Median survival time after estimated infection 12.4 months. Early infection, early onset conditions, failure thrive, generalized lymphadenopathy associated with subsequent and/or whereas lymphoid interstitial pneumonitis predictive milder disease. Conclusions. In Africa, develop disease manifestations life. Specific are HIV-1 disease, stage, death. Bimodal expression pediatric is encountered as industrialized countries, but prognosis poorer. children, vertical transmission, natural history, Africa.