Early Diagnosis of Cystic Fibrosis Through Neonatal Screening Prevents Severe Malnutrition and Improves Long-Term Growth

• DOI: 10.1542/peds.107.1.1
• Publication Date: 2004-08-13T23:55:51Z
• Authors: Philip M. Farrell; Michael R. Kosorok; Michael J. Rock; Anita Laxova; Lan Zeng; Hui-Chuan Lai; Gary Hoffman; Ronald H. Laessig; Mark L. Splaingard
• Keywords: Sweat test; Meconium Ileus

Despite its relative frequency among autosomal recessive diseases and the availability of sweat test, cystic fibrosis (CF) has been difficult to diagnose in early childhood, delays can lead severe malnutrition, lung disease, or even death. The Wisconsin CF Neonatal Screening Project was designed as a randomized clinical trial assess benefits risks diagnosis through screening. In addition, incidence determined, validity our randomization method assessed by comparing 16 demographic variables.