Long-Term Ocular Prognosis in 327 Children With Congenital Toxoplasmosis

• DOI: 10.1542/peds.113.6.1567
• Publication Date: 2004-08-14T00:53:04Z
• Authors: Martine Wallon; Laurent Kodjikian; Christine Binquet; Justus Garweg; Jacques Fleury; Catherine Quantin; François Peyron
• Keywords: Toxoplasmosis; Chorioretinitis; Congenital toxoplasmosis

Objective. Retinochoroiditis is the most frequent consequence of congenital toxoplasmosis. Early diagnosis and treatment are believed to reduce risk visual impairment. We report on clinical evolution ocular lesions final function in a prospective cohort congenitally infected children who were identified during monthly maternal prenatal screening. Methods. The study included 327 monitored for up 14 years at Croix Rousse Hospital Lyon, France. Data date infection; time type therapy; antenatal, neonatal, postnatal work-ups; status analyzed. Results. All mothers but 52 had been treated. Pyrimethamine sulfadiazine was given utero 38% after birth 72% newborns. Fansidar an average duration 337 days all 2 children. After median follow-up 6 years, 79 (24%) least 1 retinochoroidal lesion. In 23 (29%) them, new event diagnosed 10 detection first lesions: reactivation existing lesion (1 case), previously healthy location (19 cases), or both (3 cases). Fifty-five eye; 45 whom acuity data available, 31 (69%) normal vision. Twenty-four eyes; 21 11 vision eyes. None bilateral Conclusions. Clinicians, parents, elder with infection should be informed that late-onset retinal relapse can occur many overall prognosis toxoplasmosis satisfactory when early treated accordingly.