Neurodevelopmental Outcomes of Extremely Low Birth Weight Infants <32 Weeks’ Gestation Between 1993 and 1998

• DOI: 10.1542/peds.2004-2247
• Publication Date: 2005-09-01T00:36:02Z
• Authors: Betty R. Vohr; Linda L. Wright; W. Kenneth Poole; Scott A. McDonald
• Keywords: Bronchopulmonary Dysplasia

Objective. This study evaluated the impact of changes in perinatal management on neurodevelopmental impairment (NDI) at 18 to 22 months’ corrected age low gestation (22–26 weeks) and higher (27–32 extremely birth weight infants (401–1000 g weight) who were cared for National Institute Child Health Human Development Neonatal Research Network during 3 epochs (1993–1994, 1995–1996, 1997–1998). It was hypothesized that outcomes would improve over epochs. Methods. A multicenter cohort conducted 3785 with assessments age. Regression analyses completed evaluate epoch effects, gestational time plus interaction. also performed identify independent associations 4 interventions: antenatal steroids (yes, no), high-frequency ventilation number days regain as a marker nutritional intake, postnatal treatment bronchopulmonary dysplasia no) outcomes. Results. Survival improved both (55%–61%) (82%–86%) groups indicated decreased risk adverse outcome significantly lower 2 compared 1 rates Bayley Mental Index (MDI) (NDI). Antenatal associated moderate severe cerebral palsy (CP) Psychomotor Index. High-frequency MDI NDI, CP, any MDI, Index, increased NDI. Conclusion. between 1993 1998. Although some remained unchanged, scores NDI improved. steroid administration only intervention