RSV Vaccination Intention Among People Who Are or Plan to Become Pregnant

• DOI: 10.1542/peds.2023-065140
• Publication Date: 2024-04-25T08:06:31Z
• Authors: Jennifer K. Saper; Marie Heffernan; Norma-Jean E. Simon; Matthew M. Davis; Michelle L. Macy
• Keywords: Adult; Male; Adolescent; Vaccination; Respiratory Syncytial Virus Infections; Intention; Middle Aged; United States; Young Adult; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Pregnancy; Respiratory Syncytial Virus Vaccines; Humans; Female; Pregnancy Complications, Infectious

OBJECTIVES Respiratory syncytial virus (RSV) is a common pediatric infection, with young infants being at the highest risk of hospitalization and long-term sequela. New preventive agents have been recommended to prevent severe RSV illness in infants, including a vaccine administered during pregnancy. The current rates of recommended vaccination in pregnancy are suboptimal. Our objective was to characterize interest in RSV vaccination during pregnancy among people across the United States who were pregnant or planning to become pregnant.

METHODS In March 2023, we conducted a national cross-sectional online survey of individuals 18 to 45 years old who were currently pregnant or trying to become pregnant on their perceptions of RSV-related illness and intentions to get vaccinated against RSV. We performed logistic regression analyses to determine the odds and predicted proportions of the likelihood of RSV vaccination during pregnancy, controlling for sociodemographic factors.

RESULTS Of 1619 completed surveys, 1528 were analyzed. 54% of respondents indicated that they were “very likely” to get vaccinated against RSV during pregnancy. The perception of RSV as a serious illness was the strongest predictor of vaccination likelihood. In the full regression model, predicted proportions of “very likely” to vaccinate against RSV followed a similar pattern (63% if RSV infection was perceived as serious and likely, 55% if serious and unlikely, 35% if not serious; P < .001).

CONCLUSIONS Raising awareness of RSV infection as likely and potentially serious for infants may be an influential component of targeted communications that promote RSV vaccine uptake during pregnancy.