Severe Congenital Lead Poisoning in Siblings

• DOI: 10.1542/peds.2024-067808h
• Publication Date: 2024-10-01T10:59:41Z
• Authors: Suganthinie Velagala; Aditya Chhikara; Jennifer Haile
• Keywords: Chelation Therapy; Dimercaprol

Congenital lead toxicity is rare. Lead freely crosses the placenta, therefore, placing developing fetus at a higher risk for toxicity. This can to adverse consequences, such as spontaneous abortion, low birth weight, IQ, and neurodevelopmental impairment. We present rare case of siblings born mother with pica behaviors. Her venous level was 42 μg/dL time disclosure. The repeat delivery 2 weeks later 61 μg/dL. infant’s shortly after 89 neonate transferred NICU, where he received 9 doses intramuscular dimercaprol 5 days intravenous Ca2Na2EDTA. Seventy-two hours completing chelation, blood rebounded 46 A 19-day course dimercaptosuccinic acid then initiated. As 12 months age, has not required additional chelation. Shortly after, conceived another child, who prematurely 29 weeks. Twelve before delivery, mother’s 30 ug/dL. 32 ug/dL delivery. trended down without requiring Both children have since demonstrated developmental delays needed early intervention services.