Diffusion-weighted imaging–fluid-attenuated inversion recovery mismatch is associated with better neurologic response to intravenous thrombolytic therapy in acute ischemic stroke patients

• DOI: 10.15441/ceem.14.043
• Publication Date: 2015-04-01T12:46:35Z
• Authors: Jong Yeong Jeong; Sang Kuk Han; Dong Hyuk Shin; Ji Ung Na; Hyun Jung Lee; Pil Cho Choi; Jeong Hun Lee
• Keywords: Fluid-attenuated inversion recovery; Stroke; Acute stroke

To investigate differences in the effect of intravenous (IV) thrombolysis regarding mismatch diffusion-weighted imaging-fluid-attenuated inversion recovery (DWI-FLAIR) among acute ischemic stroke patients who visited emergency department (ED) within 3 hours from onset symptoms.Among ED presenting with an between January 2011 and May 2013 at a tertiary hospital, those underwent magnetic resonance imaging before IV thrombolytic therapy were included this retrospective study. Patients divided into DWI-FLAIR match groups. National Institutes Health Stroke Scale (NIHSS) scores obtained initially, 24 after therapy, on discharge, early neurologic improvement (ENI) major (MNI) compared.During study period, 50 213 presented to included. The group showed statistically significantly greater reduction NIHSS both upon discharge than did (5.5 vs. 1.2, P<0.001; 6.0 2.3, P<0.01, respectively). Moreover, ENI MNI for (27/36 2/14, 12/36 0/14, P=0.012, respectively).Among symptoms, better response terms outcome.