Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China

• DOI: 10.1556/aphysiol.101.2014.1.7
• Publication Date: 2014-03-16T01:00:49Z
• Authors: H. Wan; J. Wu; P. Sun; Yuelin Yang
• Keywords: Blood lead level; Porphobilinogen synthase

This study is to explore the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers.We conducted a cross-sectional 156 workers with between 2002 2007. The results laboratory examinations were analyzed.The authors found that 1-1 genotype associated higher blood level than those ALADl-2 genotype. Blood urine levels much storage battery cable workers. ALA ZPP serum Cr ALADl-1 was especially level.The ALAD-2 protein might modify kinetics at relatively protect against lead. Urine ALA, be considered as effective biological monitoring partners induced hematopoietic toxicology.