Development of controlled-release devices for photodynamic therapy of cancer
0211 other engineering and technologies
02 engineering and technology
0210 nano-technology
TA Engineering (General). Civil engineering (General) / általános mérnöki tudományok
3. Good health
DOI:
10.1556/pollack.2.2007.2.11
Publication Date:
2007-08-14T19:14:00Z
AUTHORS (3)
ABSTRACT
Poly (vinyl alcohol) (PVA) is a biocompatible and non-toxic polymer able to form a hydrogel network suitable for drug encapsulation and delivery. A directional controlled release device for porphyrins used in cancer therapy has been devised and implemented based on the swelling and collapse capability of the PVA-based hydrogel. An improved version of this device, having a multi-laminar design with a retarder membrane, is accomplished. The devices can function as model systems for the advanced engineering of transdermal drug-delivery devices for various therapeutic applications (photodynamic therapy, viral inactivation and treatment of psoriasis).
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