Development of controlled-release devices for photodynamic therapy of cancer

• DOI: 10.1556/pollack.2.2007.2.11
• Publication Date: 2007-08-14T19:14:00Z
• Authors: Stefan Varga; Silvia Patachia; Rodica Ion
• Keywords: Vinyl alcohol; Biocompatible material; Cancer Therapy

Poly (vinyl alcohol) (PVA) is a biocompatible and non-toxic polymer able to form hydrogel network suitable for drug encapsulation delivery. A directional controlled release device porphyrins used in cancer therapy has been devised implemented based on the swelling collapse capability of PVA-based hydrogel. An improved version this device, having multi-laminar design with retarder membrane, accomplished. The devices can function as model systems advanced engineering transdermal drug-delivery various therapeutic applications (photodynamic therapy, viral inactivation treatment psoriasis).