Lipid profile is significantly associated with sarcopenia status in elderly patients with metabolic syndrome

• DOI: 10.15562/ijbs.v18i2.577
• Publication Date: 2024-08-28T20:48:31Z
• Authors: Dwi Ngestiningsih; Mareta Isti Rosetya; Dewi Nur Fatimah; Tjokorda Gde Dale...; Muchlis Achsan Ud...

Background: Sarcopenia is a degenerative condition closely associated with the elderly, especially those with metabolic syndrome. Patients with sarcopenia often experience a decrease in muscle mass which is replaced by fat mass. Dyslipidemia through insulin resistance mechanisms can cause muscle dysfunction in the elderly. Additionally, low albumin levels can decrease muscle mass, worsening sarcopenia. Uric acid can also influence the development of sarcopenia. Sarcopenia sufferers tend to experience an increase in TNF-α levels due to insulin resistance. The incidence of metabolic syndrome with increased morbidity and mortality is more common among older individuals. The study aims to determine the relationship between lipid profile, albumin, TNF-α, and uric acid levels with sarcopenia status in elderly individuals with metabolic syndrome. Methods: An observational analytic study using a cross-sectional design. The subjects were 42 elderly individuals with metabolic syndrome. Plasma samples were used to measure lipid profile, albumin, TNF-α, and uric acid levels. Sarcopenia status was assessed through physical performance tests, hand grip strength, and BIA. Results: Total cholesterol, triglycerides, HDL, and LDL levels were significantly associated with sarcopenia status in elderly individuals with metabolic syndrome, while albumin, TNF-α, and uric acid levels were not. Conclusion: Lipid profile is significantly associated with sarcopenia status in elderly patients with metabolic syndrome.