Successful treatment of extensive uremic calciphylaxis with intravenous sodium thiosulfate and its potential in treating various diseases of pathologic calcification

• DOI: 10.15570/actaapa.2019.8
• Publication Date: 2019-03-18T11:25:43Z
• Authors: Sandra Burja; Alen Jovic; Robert Ekart; Nejc Piko; Jovan Miljkovic; Vesna Breznik
• Keywords: Calciphylaxis; Sodium thiosulfate; Angiopathy

A 72-year-old female patient presented with an end-stage renal disease on on-line hemodiafiltration and warfarin therapy advanced ulcerated calciphylaxis the lower extremities, complicated by two episodes of cellulitis. She was successfully treated for 8 months intravenous sodium thiosulfate in combination modification medication dialysis treatment, careful wound care, other supportive measures. Calciphylaxis is uncommon life-threatening systemic disease, mostly occurring patients chronic kidney risk factors. Vascular calcifications inflammation lead to thrombotic occlusions cutaneous subcutaneous arterioles, which provoke livedoid painful plaques possible progression necrotic ulcers. Conventional treatment supportive. In recent decades, off-label thiosulfate, a potent calcium chelator, antioxidant, vasodilator, has been increasingly reported be highly efficient calciphylaxis, leading significantly mortality rates. Knowledge advancement previously fatal important physicians professionals from various medical fields.