Biochemical and cellular (liver and kidney) restorative properties of garlic (Allium sativum) aqueous extract in cow brain-induced hypercholesterolemic model Swiss albino mice

• DOI: 10.15584/ejcem.2023.3.2
• Publication Date: 2023-09-29T19:21:31Z
• Authors: Swarup Kumar Kundu; Mohammad Abu Hadi...; ; Shonkor Kumar Das

Introduction and aim. Garlic is one of the most popular traditional medicinal herbs which has a number desirable health benefits. The study was designed to depict improvement serum biochemical parameters as well histomorphological recovery potential garlic aqueous extract in hypercholesterolemic mice. Material methods. A total thirty Swiss albino mice weighing 24±5g aged 5 weeks were randomly divided into three groups. Group A: supplied standard pellet water; B: + diet (cow brain: 2 g/kg b.w.t.); C: b.w.t.) (25 ml/kg b.w.t.). After four experimental tenure, samples (blood, liver, kidney) collected from each group for analysis study. Results. Compared with mice, cholesterol (TC), triglyceride (TG) concentration, low-density lipoprotein (LDL) levels significantly decreased respectively by 7%, 20% 48% along high-density (HDL) increased 47% supplemented group. Based on histological evaluation liver sample C, both portal central veins normal, fat droplets not found hepatocytes B. On other hand, unchanged renal cortex, glomerulus, Bowman’s space, kidney tubules seen C. Conclusion. Therefore, above findings present research would assist provide affirmation about cholesterol-decreasing cellular restoration potentiality extract.