Estimated Number of Cases of High-Grade Cervical Lesions Diagnosed Among Women — United States, 2008 and 2016

• DOI: 10.15585/mmwr.mm6815a1
• Publication Date: 2019-04-18T13:21:05Z
• Authors: Nancy M. McClung; Julia W. Gargano; Ina U. Park; Erin Whitney; Nasreen Abdullah; Sara Ehlers; Nancy M. Bennett; Mary Scahill; Linda M. Niccolai; Monica Brackney; Marie R. Griffin; Manideepthi Pemma...; Troy D. Querec; Angela A. Cleveland; Elizabeth R. Unger; Lauri E. Markowitz; ; ; Sheelah Blankenship; Stephanie Allen; James Meek; Kyle Higgins; James Hadler; Lynn Sosa; Kayla Saadeh; Deana Fink; Michael Silverberg; Melissa E. Powell; Shannon Q. Allain; Christina Felsen; RaeAnne Bogart; Marina Oktapodas ...; Rebecca M. Dahl
• Keywords: HPV vaccines

Human papillomavirus (HPV) causes approximately 30,000 cancers in the United States annually (1). HPV vaccination was introduced 2006 to prevent HPV-associated and diseases Cervical cancer is most common women Whereas typically take decades develop, screen-detected high-grade cervical lesions (cervical intraepithelial neoplasia grades 2 [CIN2], 3 [CIN3], adenocarcinoma situ, collectively CIN2+) develop within a few years after infection have been used monitor vaccine impact (1-3). CDC analyzed data from Papillomavirus Vaccine Impact Monitoring Project (HPV-IMPACT), population-based CIN2+ surveillance system, describe rates of among aged ≥18 during 2008-2016. Age-specific were applied U.S. population estimate total number cases diagnosed 2008* 2016. From 2008 2016, rate per 100,000 declined significantly 18-19 20-24 increased 40-64 years. In 2008, an estimated 216,000 (95% confidence interval [CI] = 194,000-241,000) diagnosed, 55% which 18-29 years; 196,000 CI 176,000-221,000) 36% During 76% attributable types targeted by currently States. These estimates likely reflect changes detection resulting updated screening management recommendations, as well primary prevention through vaccination. Increasing coverage females at routine age 11 or 12 catch-up 26 will contribute further reduction precancers.