Tuberculosis Preventive Treatment Update — U.S. President’s Emergency Plan for AIDS Relief, 36 Countries, 2016–2023

• DOI: 10.15585/mmwr.mm7311a1
• Publication Date: 2024-03-21T11:30:00Z
• Authors: Aderonke S. Ajiboye; Stephanie O’Connor; Jonathan P. Smith; Sevim Ahmedov; William L. Coggin; Macarthur Charles; Smita Ghosh; Paul Pierre; Neha Shah; Richard A. Teran; Patrick K. Moonan; Anand Date
• Keywords: Acquired Immunodeficiency Syndrome; Anti-Retroviral Agents; International Cooperation; Africa; Humans; Tuberculosis; HIV Infections; Full Report

Tuberculosis (TB) is the leading cause of death among persons with HIV.In 2022, an estimated 167,000 TB-related deaths occurred globally HIV.TB preventive treatment (TPT) helps prevent TB disease and recommended for at high risk developing TB, including those HIV.TPT, when taken antiretroviral (ART), can reduce TB-attributable 2018, U.S. President's Emergency Plan AIDS Relief (PEPFAR) program committed to offer one course TPT all eligible clients receiving ART.This analysis describes trends in initiation completion PEPFAR-supported programs 36 countries Africa, Central South America, Asia during fiscal years (FYs) 2017-2023.Overall, rates peaked FY19, a possible sign programmatic saturation.TPT who had been on ART <6 months reached 59%, overall up 87% were reported.Approximately 13 million HIV have completed since FY17, but widespread adoption shorter regimens, patient-centered approaches, electronic medical record systems might be needed ensure full coverage.Through PEPFAR's partnership national programs, has become standard care HIV.† https://www.cdc.gov/globalhivtb/who-we-are/success-stories/success-storypages/scaling-tpt-ethiopia.html§ https://www.who.int/publications/m/item/political-declaration-of-the-ungeneral-assembly-high-level-meeting-on-the-fight-against-tuberculosis¶ https://na.usembassy.gov/wp-content/uploads/sites/132/PEPFAR-COP18-Guidance_FINAL-1.