Evaluation of bioactive compounds of plants used in Mexico, to predict potential SARS-CoV-2 inhibitors: Analysis between two molecular docking servers

• DOI: 10.15741/revbio.10.e1395
• Publication Date: 2023-01-11T02:42:10Z
• Authors: Cristian Torres León; Eliseo Cárdenas-H...; Erika G. Velazque...; Jorge A. Aguirre-...; David R. Aguillón...; David Pedroza-Esc...; Nathiely Ramírez-...; Cristóbal N. Aguilar; Cristian Torres-León
• Keywords: Docking (animal); 2019-20 coronavirus outbreak; Coronavirus

Plants traditionally used for their antiviral activity could be an alternative against SARS-CoV-2. In this study, the efficacy of 10 bioactive plant compounds commonly in Mexico COVID-19 was evaluated by molecular docking with two online servers: Docking Server and DockThor. Remdesivir as a control. The results showed that Cypellocarpin B, C, Luteolin 7-glucoside Syringetin glucopyranoside highest affinity towards viral proteins Mpro RdRp respect to Remdesivir. Comparison servers differences motors available on each server. use represents treatment patients COVID-19.