Effect of Fish Oil-based Intravenous Fat Emulsion with Parenteral Nutrition in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

• DOI: 10.15747/jcn.2016.8.1.29
• Publication Date: 2016-05-04T06:15:50Z
• Authors: Ji Hyeong Choe; Young Joo Lee; Hye Jung Bae; Sun Hoi Jung; Hyeon Joo Hahn; Yungil Koh
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Purpose: Omega-3 fatty acid is known for immunonutrition in that it has anti-inflammatory properties and improves the patients’ immune function. The objective of this study was to determine the effects of a fish oil-based lipid emulsion for adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Methods: This was a retrospective study of 90 adult allogeneic HSCT patients from July 2011 to June 2015. The patients were divided into two groups according to the lipid type provided; fish oil group (FO group, n=55) and non-fish oil group (NFO group, n=35). The demographics, parenteral nutrition and lipid emulsion duration, length of hospital stay (LOS), weight change, 30 day mortality, survival period, incidence of acute graft-versus-host disease (aGVHD), neutropenic fever, sepsis, and re-hospitalization were collected from the electronic medical records. Results: The patients’ characteristics including age, sex, body mass index, and underlying disease were similar in the two groups. The incidence of aGVHD and infectious complications, mortality, LOS, re-hospitalization were also similar. The FO group showed weight gains, whereas the NFO group showed weight loss (FO vs. NFO=0.34% vs. −1.08%, P=0.245). Conclusion: The clinical outcomes were similar in the two groups but there was a tendency for gain weight in the FO group. A large, well designed study, and a dosing study will also be needed to determine the optimal dose range for HSCT patients.