Hemoglobin calabria leading to undetectable hemoglobin A1C

• DOI: 10.15761/imc.1000131
• Publication Date: 2020-03-17T12:36:27Z
• Authors: Itir Sirinoglu De...; Isil Ozbas Tevetoglu; Bülent Uyanık; Soner Erdin
• Keywords: Hemoglobin s; Hemoglobin A

More than 12,000 hemoglobin (Hb) variants have been identified and listed on the HbVar database.Reliable detection of these Hb is important for planning hemoglobinopathy screening genetic counseling.Presumptive diagnosis usually dependent dedicated analyzers, e.g.high-performance liquid chromatography (HPLC) or capillary electrophoresis (CE) systems specifically developed fraction separation quantification.In most cases, simple can be easily identified.Rarely, a novel molecule formed by assembly different defective globin chains could complicate clinical laboratory diagnostics requires DNA testing.