Biocompatibility Studies of the Anaconda Stent-Graft and Observations of Nitinol Corrosion Resistance

• DOI: 10.1583/03-1143.1
• Publication Date: 2005-01-05T19:25:23Z
• Authors: Robert Guidoin; Yvan Douville; Michel F. Baslé; Martin King; Georgi R. Marinov; Amidou Traoré; Ze Zhang; Fabien Guillemot; Guy Dionne; Ruwan Sumanasinghe; André-Pierre Legrand; Marie-France Guidoin; Marie-Christine P...; Charles Baquey
• Keywords: Biocompatibility; Endovascular aneurysm repair

Purpose:To validate the deployment, in vivo performance, biostability, and healing capacity of Anaconda self-expanding endoprosthesis a canine aortic aneurysm model. Methods:Aneurysms were surgically created 12 dogs by sewing woven polyester patch onto anterior side thoracic or abdominal aorta. prostheses implanted transfemorally for prescheduled periods (1 3 months). Aneurysm exclusion stent-graft patency monitored angiographically. Healing was assessed with histological analysis scanning electron microscopy (SEM). Textile determined physical chemical stability material, while biostability nitinol wires evaluated SEM spectroscopy. Results:All intact at explantation. After 1 month, endothelial-like cells migrating discontinuous manner both proximally distally over internal collagenous pannus device-host boundary. months, endothelialization had reached midsections devices, thicker capsule. Patches sharing luminal surface thrombotic deposits. However, wall device level generally poorly healed, multiple thrombi scattered irregularly surface. The fabric except some filaments that ruptured adjacent to sutures abrasion caused wires. No evidence corrosion found on stents. Conclusions:This has demonstrated its ability exclude arterial aneurysms. used this study an experimental prototype, manufacturer incorporated new immobilization features into model clinical use. constituent materials appear be suitable terms biocompatibility, biofunctionality, short-term durability.