Secondary metabolites of a marine-derived Penicillium ochrochloron

• DOI: 10.15835/nsb13311020
• Publication Date: 2021-09-27T17:57:57Z
• Authors: Peter M. EZE; Ying GAO; Yang LIU; Lasse Van GEELEN; Chika P. EJIKEUGWU; Charles O. ESIMONE; Festus B. C. OKOYE; Peter PROKSCH; Rainer KALSCHEUER
• Keywords: Marine fungi; Acinetobacter baumannii; Shewanella putrefaciens

Extremophilic fungi have received considerable attention recently as new promising sources of biologically active compounds with potential pharmaceutical applications. This study investigated the secondary metabolites a marine-derived Penicillium ochrochloron isolated from underwater sea sand collected North Sea in St. Peter-Ording, Germany. Standard techniques were used for fungal isolation, taxonomic identification, fermentation, extraction, and isolation metabolites. Chromatographic separation spectroscopic analyses yielded eight compounds: talumarin A (1), aspergillumarin (2), andrastin (3), clavatol (4), 3-acetylphenol (5), methyl 2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furanpropanoate (6), emodin (7) 2-chloroemodin (8). After co-cultivation Bacillus subtilis, fungus was induced to express (-)-striatisporolide (9). Compound 1 evaluated antibacterial activity against Staphylococcus aureus, Acinetobacter baumannii, Mycobacterium smegmatis, M. tuberculosis, well cytotoxicity THP-1 cells. The compound, however, not cytotoxic cells had no microorganisms tested. P. this are well-known wide range beneficial biological properties that can be explored pharmaceutical, agricultural, or industrial highlights bioprospecting marine confirms useful strategy discovery natural products.